Description

7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-1-Methyl-2H-1,4-Benzodiazepin-2-One is a high-purity benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for analytical and process development purposes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing.
• Pharmacological Research: Serves as a lead compound or a precursor for structure-activity relationship (SAR) studies in neuroscience and medicinal chemistry.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of related therapeutic molecules.
• Impurity Standard: Utilized as a certified reference material (CRM) to identify and quantify related substances in final drug products.
• Academic Research: Used in university and institutional labs for studying benzodiazepine chemistry and biochemistry.

Basic Information

Product Name	7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-1-Methyl-2H-1,4-Benzodiazepin-2-One
CAS No.	52391-89-6
Molecular Formula	C₁₆H₁₂ClFN₂O₂
Molecular Weight	318.73 g/mol
Synonyms	3-Hydroxy-7-chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one; 1-Methyl-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; 52391-89-6; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-; Fluorophenyl benzodiazepine derivative
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-1-Methyl-2H-1,4-Benzodiazepin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.