Description

Trimethyl Chitosan is a chemically modified, water-soluble derivative of chitosan, characterized by the introduction of methyl groups onto the amine functionalities of the chitosan backbone. This quaternization significantly enhances its solubility across a wider pH range and imparts a permanent positive charge, making it a powerful cationic polymer with excellent mucoadhesive and permeation-enhancing properties. It is a critical functional biopolymer sought by the pharmaceutical, biomedical, and cosmetic industries for advanced formulation development. The compound is identified by CAS No. 52349-26-5.

Application

• Pharmaceutical Drug Delivery: As a key excipient in nasal, ocular, and oral formulations to enhance mucosal adhesion and improve the bioavailability of poorly absorbed active pharmaceutical ingredients (APIs).
• Gene Therapy & Non-Viral Transfection: Used to complex with DNA or RNA (siRNA) to form polyplex nanoparticles for safe and efficient cellular delivery in research and therapeutic applications.
• Wound Healing & Tissue Engineering: Incorporated into hydrogels, films, and scaffolds to promote hemostasis, provide antimicrobial activity, and support cell growth in advanced wound dressings and regenerative medicine.
• Cosmetic & Personal Care: Functions as a cationic conditioning agent in hair care products (shampoos, conditioners) and skin care formulations for improved texture, film-forming, and antimicrobial benefits.
• Antimicrobial Coatings: Applied to surfaces (textiles, medical devices) to create a durable, positively charged layer that disrupts bacterial cell membranes.
• Wastewater Treatment: Utilized as a highly effective flocculant for the removal of suspended solids, dyes, and other negatively charged contaminants in industrial water processes.

Basic Information

Product Name	Trimethyl Chitosan
CAS No.	52349-26-5
Molecular Formula	(C6H11NO4 • (C3H7)3)n
Molecular Weight	Variable (Polymer)
Synonyms	N,N,N-Trimethylchitosan; TMC; Chitosan, N-trimethyl; Trimethylated Chitosan; Quaternary Chitosan; N-Trimethyl Chitosan Chloride; O-Methyl Free N-Trimethyl Chitosan; TMC Chloride
EINECS	Contact for details

Quality Control

Our Trimethyl Chitosan is manufactured under a strict quality management system. Each batch is characterized and tested to ensure consistent degree of quaternization (DQ), molecular weight distribution, and purity. Comprehensive analysis includes NMR for structural confirmation, potentiometric titration for DQ, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) documenting all critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive). Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under desiccant or in a nitrogen atmosphere to prevent moisture uptake and potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder or flakes
Identification (IR)	Conforms to structure
Degree of Quaternization (DQ)	20% - 60% (Customizable)
Viscosity (1% in 1% Acetic Acid)	10 - 1000 cPs (Customizable)
Loss on Drying	≤ 10.0 %
Residue on Ignition (Ash)	≤ 1.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Microbial Count	≤ 1000 CFU/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.