Description

Ethyl 8-Ethyl-5,6,7,8-Tetrahydro-2-(Methylthio)-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and the exploration of new pharmacophores.
• API Synthesis: Used in the production of active pharmaceutical ingredients that incorporate the pyrido[2,3-d]pyrimidine core, known for its diverse biological activity.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects and scale-up activities under current Good Manufacturing Practice (cGMP) guidelines.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Ethyl 8-Ethyl-5,6,7,8-Tetrahydro-2-(Methylthio)-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	52013-82-8
Molecular Formula	C₁₅H₁₉N₃O₃S
Molecular Weight	321.40 g/mol
Synonyms	Ethyl 8-ethyl-2-(methylthio)-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylate; 6-Carbethoxy-8-ethyl-2-methylmercapto-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine; 52013-82-8; Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of Ethyl 8-Ethyl-5,6,7,8-Tetrahydro-2-(Methylthio)-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.