Description

2-Amino-3-Hydroxy-4-Hexynoic Acid is a specialized non-proteinogenic amino acid derivative featuring a unique alkyne functional group. This compound serves as a valuable chiral building block and synthetic intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and chemical manufacturers in the development of novel bioactive molecules, peptide mimetics, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to incorporate constrained, unnatural amino acid residues into peptide backbones to modulate biological activity and stability.
• Chemical Biology Probes: The alkyne moiety enables bioorthogonal labeling (e.g., via click chemistry) for studying biological processes and target identification.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective synthesis to construct complex molecular architectures.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry, biochemistry, and material science laboratories.
• Ligand and Catalyst Development: Potential precursor for creating novel chiral ligands and organocatalysts.

Basic Information

Product Name	2-Amino-3-Hydroxy-4-Hexynoic Acid
CAS No.	51995-91-6
Molecular Formula	C₆H₉NO₃
Molecular Weight	143.14 g/mol
Synonyms	4-Hexynoic acid, 2-amino-3-hydroxy-; 2-Amino-3-hydroxy-4-hexynoic acid; 3-Hydroxy-2-amino-4-hexynoic acid; (2S,3S)-2-Amino-3-hydroxy-4-hexynoic acid (for stereoisomer); AHHA; Unnatural amino acid derivative; Alkyne-containing amino acid
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Hydroxy-4-Hexynoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.