Description

2-Chloro-8-Ethyl-5,6,7,8-Tetrahydro-5-Oxo-Pyrido(2,3-D)Pyrimidine-6-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This heterocyclic compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly those with pyrido[2,3-d]pyrimidine core structures.
• API Synthesis: Serves as a crucial building block for the manufacture of Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry R&D: Used in research laboratories for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2-Chloro-8-Ethyl-5,6,7,8-Tetrahydro-5-Oxo-Pyrido(2,3-D)Pyrimidine-6-Carboxylic Acid Ethyl Ester
CAS No.	51940-32-0
Molecular Formula	C₁₄H₁₆ClN₃O₃
Molecular Weight	309.75 g/mol
Synonyms	Ethyl 2-Chloro-8-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylate; 2-Chloro-8-ethyl-5-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; 51940-32-0; Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative; 6-Carbethoxy-2-chloro-8-ethyl-5,6,7,8-tetrahydro-5-oxopyrido[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-8-Ethyl-5,6,7,8-Tetrahydro-5-Oxo-Pyrido(2,3-D)Pyrimidine-6-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.