Description

3-[3-(Trifluoromethyl)Anilino]-2-Bromo-2-Cyclohexen-1-One is a specialized fluorinated organic intermediate featuring a reactive α-bromo enone moiety. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the introduction of both trifluoromethylphenyl and bromo-cyclohexenone functional groups. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for synthesizing functionalized polymers or liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or protein interactions due to its electrophilic warhead.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, to create diverse compound libraries.

Basic Information

Product Name	3-[3-(Trifluoromethyl)Anilino]-2-Bromo-2-Cyclohexen-1-One
CAS No.	51924-70-0
Molecular Formula	C13H11BrF3NO
Molecular Weight	334.14 g/mol
Synonyms	2-Bromo-3-[(3-(trifluoromethyl)phenyl)amino]-2-cyclohexen-1-one; 3-[(3-Trifluoromethyl)anilino]-2-bromo-2-cyclohexen-1-one; 2-Bromo-3-[(3-trifluoromethylphenyl)amino]cyclohex-2-en-1-one; 2-Bromo-3-(3-trifluoromethyl-anilino)-cyclohex-2-enone; 2-Bromo-3-(α,α,α-trifluoro-m-toluidino)-2-cyclohexen-1-one
EINECS	Contact for details

Quality Control

Our 3-[3-(Trifluoromethyl)Anilino]-2-Bromo-2-Cyclohexen-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.