Description

6'-n-Methylsisomicin is a chemically modified derivative of the aminoglycoside antibiotic sisomicin, designed to enhance its pharmacological profile and combat bacterial resistance. This compound is of significant interest in pharmaceutical research and development for creating next-generation antimicrobial agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and evaluation of novel antibiotics, particularly for targeting resistant Gram-negative and Gram-positive bacterial strains.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel, semi-synthetic aminoglycoside antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate structure-activity relationships (SAR) and mechanisms of action against resistant bacteria.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation in antibiotic analysis.
• Preclinical Development: Employed in in-vitro and in-vivo studies to assess the efficacy, toxicity, and pharmacokinetics of new antibiotic candidates.

Basic Information

Item	Detail
Product Name	6'-n-Methylsisomicin
CAS No.	51909-61-6
Molecular Formula	C₂₁H₄₁N₅O₇
Molecular Weight	475.58 g/mol
Synonyms	6'-N-Methylsisomicin; 6'-Methylsisomicin; Antibiotic G 52; Antibiotic G-52; Sisomicin, 6'-N-methyl-; 4-O-(2,6-Diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl)-6-O-(3-deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl)-1-N-[3-amino-3-deoxy-α-D-glucopyranosyl]-2-deoxy-D-streptamine
EINECS	Contact for details

Quality Control

Our 6'-n-Methylsisomicin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.