Description

[Sar1, Gly8]-Angiotensin II Acetate Hydrate is a synthetic peptide analog of the potent vasoconstrictor hormone Angiotensin II, modified at positions 1 and 8. This compound is a critical research tool for studying the renin-angiotensin system (RAS), cardiovascular physiology, and receptor pharmacology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular drug discovery and metabolic research.

Application

• Biomedical Research: A key reference standard and agonist/antagonist in studies of the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation.
• Pharmacological Studies: Used to investigate Angiotensin II receptor (AT1 and AT2) binding, signaling pathways, and functional responses in vitro and in vivo.
• Drug Discovery & Development: Serves as a lead compound or a comparative control in the screening and development of novel cardiovascular therapeutics, including receptor blockers.
• Biochemical Assays: Employed in enzyme activity assays (e.g., ACE inhibition studies) and as a calibrant in analytical methods like HPLC and mass spectrometry.
• Cell Culture & Physiology: Applied in cellular models to study effects on vascular smooth muscle contraction, cardiac hypertrophy, and renal function.

Basic Information

Product Name	[Sar1, Gly8]-Angiotensin II Acetate Hydrate
CAS No.	51887-62-8
Molecular Formula	C45H68N14O11 • xC2H4O2 • yH2O
Molecular Weight	~997.1 g/mol (anhydrous free base)
Synonyms	Saralasin Acetate Hydrate; [Sar1,Gly8]-Ang II; [1-Sarcosine,8-Glycine]-Angiotensin II; Angiotensin II Antagonist; Sarcosyl1,Gly8-Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Gly (1-Sar,8-Gly); Sar1,Gly8 Angiotensin II Acetate; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Gly-OH (1-Sar)
EINECS	Contact for details

Quality Control

Our [Sar1, Gly8]-Angiotensin II Acetate Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, acetate counter-ion, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 10.0%
Acetate Content (IC)	5.0% - 12.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.