Description

Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl Methyl Ester is a synthetic peptide derivative, specifically the methyl ester of the pentapeptide pGlu-His-Trp-Ser-Tyr. This compound is a key intermediate in the synthesis of complex peptide hormones and serves as a valuable building block for advanced biochemical research and pharmaceutical development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of peptide hormones and related analogs for therapeutic development.
• Biochemical Research: Used as a reference standard and precursor in studies of peptide structure, function, and metabolism.
• Peptide Library Synthesis: Employed in combinatorial chemistry for creating diverse peptide libraries for drug discovery screening.
• Diagnostic Agent Development: Serves as a component in the development of peptide-based diagnostic assays and imaging probes.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental and applied peptide science.

Basic Information

Product Name	Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl Methyl Ester
CAS No.	51871-39-7
Molecular Formula	C38H45N9O10
Molecular Weight	787.82 g/mol
Synonyms	pGlu-His-Trp-Ser-Tyr-OMe; L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester; pGlu-His-Trp-Ser-Tyr Methyl Ester; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl methyl ester; Pyroglutamylhistidyltryptophylseryltyrosine methyl ester; PHWSerTyr-OMe
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), peptide content, and residual solvent levels. We adhere to cGMP principles for the manufacture of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.