Description

Insulin, 3-Iodo-Tyr(A14)- CAS NO 51798-73-3 is a chemically modified insulin analogue where the tyrosine residue at position A14 is specifically iodinated. This modification is critical for research applications, particularly in the study of insulin receptor binding, metabolic pathways, and protein structure-function relationships. It serves as an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic development in the life sciences sector.

Application

• Biochemical Research: Used as a tracer or labeled ligand in receptor binding assays and competitive inhibition studies to investigate insulin signaling mechanisms.
• Metabolic Studies: Employed in research focused on glucose metabolism, insulin action, and the pathophysiology of diabetes.
• Structural Biology: Acts as a probe in X-ray crystallography, NMR spectroscopy, and other techniques to elucidate the three-dimensional structure of insulin and its complexes.
• Pharmaceutical Development: Serves as a reference standard or intermediate in the development and validation of novel insulin-based therapeutics and diagnostic kits.
• Radioligand Preparation: The iodinated tyrosine residue provides a site for further radioactive labeling (e.g., with I-125) for highly sensitive detection in autoradiography and radioimmunoassays (RIA).

Basic Information

Product Name	Insulin, 3-Iodo-Tyr(A14)-
CAS No.	51798-73-3
Molecular Formula	C257H383N65O77S6
Molecular Weight	5809.5 g/mol (approx.)
Synonyms	3-Iodo-L-tyrosine(A14)-insulin; A14-3-Iodo-L-tyrosine-insulin; 3-I-Tyr(A14)-Insulin; Insulin (human) iodinated at Tyr-A14; Monoiodoinsulin (A14); Insulin, iodinated at tyrosine A14; Tyr(A14)-monoiodo-insulin
EINECS	Contact for details

Quality Control

Our Insulin, 3-Iodo-Tyr(A14)- is produced and handled under stringent quality protocols suitable for research applications. Each batch is characterized to ensure high purity and structural integrity. Comprehensive analysis includes determination of iodination specificity, peptide content, and biological activity. Certificates of Analysis (COA) detailing purity (by HPLC), identity (by MS), and other relevant parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Single-Iodination Specificity (Tyr A14)	≥ 90%
Peptide Content	≥ 80% (by weight)
Biological Activity	Assessed by receptor binding assay
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.