Description

Insulin, Des-Phe(B1)-Des-Val(B2)- is a synthetic peptide analog of human insulin, specifically modified by the removal of the phenylalanine and valine residues from the B-chain. This compound is a critical intermediate in pharmaceutical research and development, particularly for studying insulin structure-activity relationships and for the synthesis of novel insulin analogs. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in metabolic disorder research and advanced peptide synthesis.

Application

• Pharmaceutical Intermediate: Key starting material for the chemical synthesis and research of novel insulin analogs and derivatives.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating insulin receptor binding, signaling pathways, and metabolism.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the functional domains of insulin by comparing the properties of this des-modified form with native insulin.
• Peptide Chemistry Development: Serves as a model compound in the development and optimization of solid-phase peptide synthesis (SPPS) and purification techniques.
• Analytical Standard: Employed in quality control laboratories for method development and validation in HPLC and mass spectrometry analyses of insulin-related products.

Basic Information

Product Name	Insulin, Des-Phe(B1)-Des-Val(B2)-
CAS No.	51798-70-0
Molecular Formula	C252H381N65O76S6
Molecular Weight	5739.4 g/mol
Synonyms	Des-Phe(B1)-Des-Val(B2)-Insulin; B(3-29)-Insulin; Insulin (human) B(3-29); Human Insulin Des-Phe(B1)-Des-Val(B2)-; Insulin B-Chain(3-29); [Des-Phe(B1),Des-Val(B2)]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Des-Phe(B1)-Des-Val(B2)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.