Description

α-(3-Chloropropyl)-4-Fluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a reactive chloropropyl chain and a fluorinated aromatic ring, makes it indispensable for constructing complex molecules with high precision. This intermediate is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Building block for advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for high-performance displays.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for introducing fluorinated and reactive chloropropyl groups into polymer chains.
• Organic Synthesis Reagent: Employed in asymmetric synthesis and catalysis research to introduce chiral fluorinated benzyl motifs.
• Chemical Research: Valuable reference standard and starting material in academic and industrial R&D for exploring new fluorination methodologies.

Basic Information

Item	Information
Product Name	α-(3-Chloropropyl)-4-Fluorobenzyl Alcohol
CAS No.	51787-87-2
Molecular Formula	C10H12ClFO
Molecular Weight	202.65 g/mol
Synonyms	4-Fluoro-α-(3-chloropropyl)benzyl alcohol; (4-Fluorophenyl)(3-chloropropoxy)methanol; 1-(4-Fluorophenyl)-3-chloropropan-1-ol; 3-Chloro-1-(4-fluorophenyl)-1-propanol; α-(3-Chloropropyl)-4-fluorobenzyl alcohol; 51787-87-2; (RS)-1-(4-Fluorophenyl)-3-chloropropan-1-ol
EINECS	Contact for details

Quality Control

Our production of α-(3-Chloropropyl)-4-Fluorobenzyl Alcohol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess where applicable. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a cGMP-compliant quality system suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.