Description

Histidinohydroxymerodesmosine is a complex, naturally occurring amino acid derivative and a specific biomarker of collagen and elastin cross-linking. This compound matters significantly in biochemical research and advanced material science for its role in understanding tissue maturation, aging, and stability. It is primarily needed by researchers and manufacturers in the fields of biochemistry, analytical chemistry, and life science research, particularly for studies related to connective tissue disorders and the development of diagnostic assays.

Application

• Biochemical Research: Used as a reference standard in the study of collagen and elastin cross-linking mechanisms and tissue aging.
• Diagnostic Development: Serves as a critical biomarker for developing assays to quantify advanced glycation end-products (AGEs) and related metabolic disorders.
• Pharmaceutical Research: Employed in preclinical studies investigating compounds that may inhibit or reverse excessive cross-linking in pathological conditions.
• Life Science Reagents: A key component in high-purity reagent kits for proteomics and metabolomics analysis.
• Material Science: Investigated for its role in the structural properties of biological materials to inspire synthetic polymer design.
• Academic Research: Utilized in university and institutional labs for fundamental research into extracellular matrix biology.

Basic Information

Product Name	Histidinohydroxymerodesmosine
CAS No.	51773-61-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Histidinohydroxymerodesmosine; Histidinyl-hydroxymerodesmosine; HHL; Merodesmosine derivative; Histidine-containing crosslink; AGE biomarker; Collagen cross-link amino acid; Elastin cross-link compound
EINECS	Contact for details

Quality Control

Our Histidinohydroxymerodesmosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including chromatographic purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.