Description

2-Amino-3-Fluorobenzoyl-5-Methylthiophene is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both amino and fluorobenzoyl functionalities on a thiophene core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical developers engaged in the discovery of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and thiophene ring can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials due to its conjugated system.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex fluorinated aryl-thiophene motifs.
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research to study the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	2-Amino-3-Fluorobenzoyl-5-Methylthiophene
CAS No.	51687-28-6
Molecular Formula	C12H10FNOS
Molecular Weight	235.28 g/mol
Synonyms	2-Amino-3-fluoro-5'-(methylthio)[1,1'-biphenyl]-4-carboxaldehyde; 5-Methyl-2-[(3-fluoro-2-aminophenyl)carbonyl]thiophene; 3-Fluoro-2-(5-methylthiophene-2-carbonyl)aniline; (3-Fluoro-2-aminophenyl)(5-methylthiophen-2-yl)methanone; 2-Amino-3-fluorobenzoyl-5-methylthiophene; 51687-28-6
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3-Fluorobenzoyl-5-Methylthiophene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.