Description

4-Chloro-2-(Methylthio)-5,6,7,8-Tetrahydroquinazoline is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydroquinazoline class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is essential for research and development chemists, process scale-up specialists, and manufacturers within the global pharmaceutical and agrochemical industries seeking reliable, high-quality intermediates for innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its heterocyclic structure for biological activity.
• Chemical Synthesis Building Block: Serves as a versatile scaffold for constructing more complex molecular architectures in medicinal chemistry.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for exploratory research and method development.
• Process Chemistry & Scale-Up: Critical for optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	4-Chloro-2-(Methylthio)-5,6,7,8-Tetrahydroquinazoline
CAS No.	51660-11-8
Molecular Formula	C9H11ClN2S
Molecular Weight	214.71 g/mol
Synonyms	4-Chloro-2-methylsulfanyl-5,6,7,8-tetrahydroquinazoline; 2-(Methylthio)-4-chloro-5,6,7,8-tetrahydroquinazoline; 4-Chloro-2-(methylmercapto)-5,6,7,8-tetrahydroquinazoline; 5,6,7,8-Tetrahydro-4-chloro-2-(methylthio)quinazoline; 51660-11-8; Quinazoline, 4-chloro-2-(methylthio)-5,6,7,8-tetrahydro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Methylthio)-5,6,7,8-Tetrahydroquinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.