Description

Z-D-Glu(Otbu)-Oh is a protected glutamic acid derivative, specifically the Z-protected D-glutamic acid γ-tert-butyl ester. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-glutamic acid residues with orthogonal side-chain protection.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for targeted therapies.
• Biochemical Research: Employed in studying enzyme-substrate interactions, receptor binding, and metabolic pathways involving glutamic acid.
• Proteomics & Diagnostics: Used in the preparation of specialized peptide standards, antigens, or probes for diagnostic assays.
• Material Science: Potential applications in the development of bio-inspired polymers and functional biomaterials.

Basic Information

Product Name	Z-D-Glu(Otbu)-Oh
CAS No.	51644-83-8
Molecular Formula	C₁₆H₂₁NO₆
Molecular Weight	323.34 g/mol
Synonyms	N-Carbobenzoxy-D-glutamic acid γ-tert-butyl ester; Z-D-Glu(OtBu)-OH; (R)-2-((((Benzyloxy)carbonyl)amino)pentanedioic acid 5-tert-butyl ester; D-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester; N-Cbz-D-glutamic acid 5-tert-butyl ester; Z-D-Glu(OtBu); CBZ-D-Glutamic acid γ-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Glu(Otbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.