Description

2,2,2-Trifluoro-1-Phenyl-Ethylamine is a versatile fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a trifluoroethyl group attached to a phenylamine core, makes it a valuable precursor for introducing fluorine atoms into complex molecules, thereby modulating their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) agents and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into the synthesis of specialty polymers, liquid crystals, and advanced organic frameworks to impart unique electronic and surface properties.
• Fluorine Chemistry Research: A fundamental reagent for studying structure-activity relationships (SAR) and developing new fluorination methodologies.
• Diagnostic Agent Precursor: Potential intermediate in the development of fluorinated contrast agents or radiotracers for medical imaging.

Basic Information

Product Name	2,2,2-Trifluoro-1-Phenyl-Ethylamine
CAS No.	51586-24-4
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	α-(Trifluoromethyl)benzylamine; (2,2,2-Trifluoro-1-phenylethyl)amine; 1-Phenyl-2,2,2-trifluoroethylamine; 2,2,2-Trifluoro-1-phenylethanamine; Benzenemethanamine, α-(trifluoromethyl)-; TFPEA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-Phenyl-Ethylamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (by GC/HPLC), impurity profile, and physical characteristics. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.