Description

H-Ser(Tbu)-Otbu Hcl is a protected serine derivative, specifically the tert-butyl ether of the hydroxyl group and the tert-butyl ester of the carboxylic acid, supplied as its hydrochloride salt. This compound is a critical building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), where it provides orthogonal protection strategies to prevent unwanted side reactions. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on peptide chemistry and drug discovery.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled assembly of peptide chains.
• Solution-Phase Peptide Synthesis: Used in the preparation of peptide fragments and complex natural products.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the manufacture of peptide-based therapeutics and APIs.
• Bioconjugation and Labeling: Provides a handle for the site-specific modification of peptides and proteins after deprotection.
• Research & Development: Employed in academic and industrial labs for exploring new peptide structures and biological activities.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new drug candidates.

Basic Information

Item	Detail
Product Name	H-Ser(Tbu)-Otbu Hcl
CAS No.	51537-21-4
Molecular Formula	C11H24ClNO3
Molecular Weight	253.77 g/mol
Synonyms	Serine, O-tert-butyl-, 1,1-dimethylethyl ester, hydrochloride; H-Ser(OtBu)-OtBu·HCl; O-tert-Butyl-L-serine tert-butyl ester hydrochloride; L-Serine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester, hydrochloride; N-[(tert-Butoxy)carbonyl]-O-tert-butyl-L-serine; Boc-Ser(OtBu)-OH (related protected form); Fmoc-Ser(tBu)-OH (related protected form); Protected Serine derivative HCl salt
EINECS	Contact for details

Quality Control

Our H-Ser(Tbu)-Otbu Hcl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.