Description

Pyrimidine, 4-Chloro-2-Fluoro- (9Ci) is a halogenated pyrimidine derivative, a crucial heterocyclic building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with tailored biological and material properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, as well as by material scientists exploring novel electronic or polymeric structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and CNS-active compound libraries.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Pyrimidine, 4-Chloro-2-Fluoro- (9Ci)
CAS No.	51422-00-5
Molecular Formula	C4H2ClFN2
Molecular Weight	132.52 g/mol
Synonyms	4-Chloro-2-fluoropyrimidine; 2-Fluoro-4-chloropyrimidine; 4-Chloro-2-fluoro-1,3-diazine; 2-Fluoro-4-chloro-1,3-diazine; 4-Chloro-2-fluoropyrimidine (9CI); 4-Chloro-2-fluoro-pyrimidine; 2-Fluoro-4-chloro-1,3-diazabenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-fluoropyrimidine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced analytical techniques such as GC, HPLC, and NMR. We are committed to meeting the stringent requirements of research and cGMP (where applicable) environments, and specifications can be aligned with client-specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.