Description

4-Chloro- L-Phenylalanine, Ethyl Ester, Hydrochloride (1:1) is a protected amino acid derivative, specifically the ethyl ester hydrochloride salt of 4-chloro-L-phenylalanine. This compound is a critical chiral building block and intermediate in the synthesis of complex peptides and pharmaceutical active ingredients. It is essential for research and production in pharmaceutical development, particularly for creating novel therapeutic agents and conducting biochemical studies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in proteomics, enzyme-substrate studies, and as a precursor for labeled compounds in metabolic pathway analysis.
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Agrochemical Development: Potential intermediate for designing novel, chiral agrochemicals and plant growth regulators.
• Academic & Industrial R&D: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-Chloro- L-Phenylalanine, Ethyl Ester, Hydrochloride (1:1)
CAS No.	51366-22-4
Molecular Formula	C11H15ClNO2 • HCl
Molecular Weight	278.16 g/mol
Synonyms	L-4-Chlorophenylalanine ethyl ester hydrochloride; (S)-2-Amino-3-(4-chlorophenyl)propanoic acid ethyl ester hydrochloride; 4-Chloro-L-Phe-OEt • HCl; Ethyl (2S)-2-amino-3-(4-chlorophenyl)propanoate hydrochloride; 4-Cl-L-Phe-OEt • HCl; 4-Chloro-DL-phenylalanine ethyl ester hydrochloride (racemic mixture reference); Fmoc-4-chloro-L-phenylalanine ethyl ester precursor
EINECS	Contact for details

Quality Control

Our 4-Chloro- L-Phenylalanine, Ethyl Ester, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.