Description

Alprazolam CAS NO 51339-48-1 is a high-purity active pharmaceutical ingredient (API) belonging to the benzodiazepine class of compounds. It is a critical intermediate and reference standard for pharmaceutical research, development, and quality control laboratories worldwide. This compound is essential for manufacturers and researchers in the pharmaceutical and analytical chemistry sectors who require a reliable and consistent supply of a well-characterized substance for the production of finished dosage forms and analytical method validation.

Application

• Pharmaceutical API Manufacturing: Primary active ingredient for the formulation of anxiolytic and panic disorder medications.
• Reference Standard: Certified material for use in quality control (QC) and quality assurance (QA) laboratories to verify the identity, purity, and potency of drug products.
• Research & Development: Key intermediate in the synthesis of novel pharmaceutical compounds and for pharmacological studies within academic and industrial R&D settings.
• Analytical Method Development: Used to develop, validate, and calibrate analytical techniques such as HPLC, GC, and spectroscopy in compliance with ICH guidelines.
• Regulatory Submissions: Sourced for generating data required for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDA).
• Clinical Trial Material: Used in the production of batches for clinical studies to ensure safety and efficacy.

Basic Information

Product Name	Alprazolam
CAS No.	51339-48-1
Molecular Formula	C17H13ClN4
Molecular Weight	308.76 g/mol
Synonyms	8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine; Xanax (Trade Name); Alprazolamum; U-31889; Tafil; Alprox; Alzam; Frontin; Zolam; Tranax; Restyl
EINECS	Contact for details

Quality Control

Our Alprazolam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, consistent with ICH Q3A/B guidelines. A Certificate of Analysis (COA) detailing results from tests including Identification (IR, HPLC), Assay (HPLC), Related Substances (HPLC), Residual Solvents (GC), and Loss on Drying is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.