Description

Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2 is a synthetic decapeptide amide, a potent analog of Gonadotropin-Releasing Hormone (GnRH). This compound matters for its high biological activity and specificity in modulating the hypothalamic-pituitary-gonadal axis. It is primarily needed by pharmaceutical R&D teams, clinical research organizations, and manufacturers of active pharmaceutical ingredients (APIs) for developing advanced therapeutic and diagnostic applications.

Application

• Pharmaceutical Research & Development: As a key reference standard and intermediate in the development of novel GnRH-based therapeutics.
• Endocrinology Studies: For in vitro and in vivo research into reproductive biology, hormone regulation, and related metabolic pathways.
• API Manufacturing: Serves as a critical building block in the synthesis of complex peptide-based active pharmaceutical ingredients.
• Clinical Diagnostics: Potential use in the development of immunoassays and diagnostic kits for hormonal disorders.
• Biochemical Tool Compound: Used in receptor binding assays and signal transduction studies to investigate GnRH receptor function.
• Veterinary Medicine: Research into applications for animal reproduction management and fertility control.

Basic Information

Product Name	Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2
CAS No.	51230-19-4
Molecular Formula	C₆₀H₈₆N₁₈O₁₄
Molecular Weight	1267.5 g/mol
Synonyms	GnRH Agonist Decapeptide; Gonadorelin Analog; Luteinizing Hormone-Releasing Hormone (LHRH) Agonist; Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl-D-Alanyl-Leucyl-Arginyl-Prolyl-Glycinamide; [D-Ala⁶]-GnRH; [D-Ala⁶]-LHRH; [Des-Gly¹⁰, D-Ala⁶]-LHRH Ethylamide; Fertirelin Acetate (related salt form)
EINECS	Contact for details

Quality Control

Our Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider storage under an inert atmosphere or desiccant to minimize degradation due to its hygroscopic nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.