Description

Boc-Arg(Z)2-Oh CAS NO 51219-19-3 is a protected derivative of the amino acid arginine, featuring tert-butoxycarbonyl (Boc) and benzyloxycarbonyl (Z) protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of arginine residues into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, antimicrobial peptides, and enzyme inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-conjugates used in diagnostic assays and imaging.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry and peptide science.

Basic Information

Product Name	Boc-Arg(Z)2-Oh
CAS No.	51219-19-3
Molecular Formula	C₂₆H₄₂N₄O₇
Molecular Weight	522.64 g/mol
Synonyms	Nα-Boc-Nω, Nω'-bis(Cbz)-L-arginine; Boc-Arg(Boc)2-OH (common alternate notation); tert-Butyl N-[(2S)-5-[(benzyloxy)carbonylamino]-1-[[(benzyloxy)carbonyl]amino]pentan-2-yl]carbamate; Nα-(tert-Butoxycarbonyl)-Nω,Nω'-bis(benzyloxycarbonyl)-L-arginine; Boc-L-Arg(Z)2-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-5-{[(benzyloxy)carbonyl]amino}-N-[(benzyloxy)carbonyl]pentanamide; L-Arginine, N2-[(1,1-dimethylethoxy)carbonyl]-N5,N5-bis[(phenylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Boc-Arg(Z)2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in GMP-oriented applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-10.0° to -12.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.