Description

S(-)-Thioamylal Sodium is the sodium salt derivative of the thiobarbiturate anesthetic agent, thioamylal. This compound is a key chiral intermediate and reference standard in pharmaceutical research and development, particularly for studying the stereoselective metabolism and activity of barbiturate derivatives. It is essential for analytical chemists, pharmacologists, and process development scientists working in central nervous system (CNS) drug discovery and quality control laboratories.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control testing of active pharmaceutical ingredients (APIs) and related substances.
• Chiral Intermediate Synthesis: Serves as a critical building block for the synthesis of enantiomerically pure barbiturate analogs and novel therapeutic agents targeting specific receptor sites.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo research to investigate the stereospecific absorption, distribution, metabolism, and excretion (ADME) profiles of thiobarbiturates.
• Biochemical Research: Utilized in studies exploring the mechanism of action of anesthetic and sedative-hypnotic drugs at GABAA receptors and other neuronal targets.
• Impurity Profiling: Acts as a known impurity or degradation product standard for stability-indicating assays in the manufacturing of related pharmaceutical compounds.

Basic Information

Product Name	S(-)-Thioamylal Sodium
CAS No.	51165-41-4
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.32 g/mol
Synonyms	(-)-Thioamylal Sodium Salt; (S)-5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid Sodium Salt; Sodium (S)-5-Allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; S(-)-Thiamylal Sodium; Thioseconal Sodium (S-enantiomer); 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid Sodium Salt (S-isomer); NSC 401443 (S-form)
EINECS	Contact for details

Quality Control

Our S(-)-Thioamylal Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and related substances is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.