Description

S-(-)-Thiopental Sodium is the sodium salt of the S-enantiomer of thiopental, a potent ultra-short-acting barbiturate. This specific stereoisomer is of significant interest in pharmaceutical research and development due to its distinct pharmacological profile. It is a critical compound for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly those focused on neuropharmacology, anesthetic development, and stereochemistry studies. Its high purity is essential for ensuring reliable and reproducible experimental and formulation outcomes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Anesthetic Research: Serves as a key active pharmaceutical ingredient (API) intermediate in preclinical and clinical research for ultra-short-acting intravenous anesthetics.
• Neuropharmacological Studies: Employed in neuroscience research to study GABAA receptor modulation, mechanisms of anesthesia, and sedation.
• Stereochemical Synthesis: Acts as a chiral building block or intermediate in the asymmetric synthesis of more complex therapeutic agents.
• Forensic and Toxicology Standards: Utilized in analytical laboratories for calibrating equipment and validating methods in forensic science and clinical toxicology.
• Biochemical Assay Development: Applied in the development of in-vitro assays to screen for compounds with similar pharmacological activity or to study drug-receptor interactions.

Basic Information

Product Name	S-(-)-Thiopental Sodium
CAS No.	51165-39-0
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.32 g/mol
Synonyms	(S)-Thiopental Sodium; (-)-Thiopental Sodium; S-Thiopental Sodium; Pentothal Sodium (S-enantiomer); 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt (S-form); Sodium 5-ethyl-5-(1-methylbutyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dionate; Thiomebumal Sodium (S-enantiomer); NSC-40166 (S-form)
EINECS	Contact for details

Quality Control

Our S-(-)-Thiopental Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), chiral excess, and related substances is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. The container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.