Description

R-(+)-Thiopental Sodium is the dextrorotatory enantiomer of the ultra-short-acting barbiturate anesthetic, thiopental sodium. This specific stereoisomer is of significant interest in pharmaceutical research for studying stereoselective pharmacokinetics, pharmacodynamics, and receptor interactions. It is primarily utilized by research institutions, pharmaceutical development laboratories, and analytical service providers engaged in chiral drug development, neuropharmacology studies, and forensic analysis.

Application

• Chiral Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development and validation in HPLC, GC, and chiral separation techniques.
• Pharmacological Research: Critical for in vitro and in vivo studies investigating the stereospecific effects, metabolism, and clearance mechanisms of barbiturate anesthetics.
• Neuroscience Studies: Employed in research focused on GABAA receptor modulation, anesthesia mechanisms, and central nervous system depression.
• Forensic Toxicology: Serves as a calibrant or control material in forensic labs for the precise identification and quantification of thiopental enantiomers in biological samples.
• Drug Development & Impurity Profiling: Used to identify and quantify the R-(+) enantiomer as a potential impurity or degradation product in S-(-)-thiopental sodium (the active pharmaceutical ingredient) batches.
• Academic Research & Teaching: Utilized in university laboratories for advanced courses in medicinal chemistry, stereochemistry, and anesthesiology.

Basic Information

Product Name	R-(+)-Thiopental Sodium
CAS No.	51165-38-9
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.32 g/mol
Synonyms	(R)-(+)-Thiopental Sodium; Dextro-Thiopental Sodium; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt, (R)-enantiomer; Sodium 5-ethyl-5-(1R-methylbutyl)-2-thiobarbiturate; R-Thiopentone Sodium; (+)-Thiopental Sodium; Pentothal Sodium (R-enantiomer)
EINECS	Contact for details

Quality Control

Our R-(+)-Thiopental Sodium is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, enantiomeric excess (ee) determination, and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing purity, specific rotation, and related substance profiles is provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant use and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Specific Rotation)	[α]D20: +40° to +50° (c=1 in H2O)
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Excess (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.