Description

Substance P (5-11) CAS NO 51165-09-4 is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 5 through 11. This fragment is a critical research tool for investigating the structure-activity relationships and signaling pathways of the full Substance P molecule, particularly its interaction with neurokinin receptors. It is essential for researchers and developers in neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptides for biochemical assays and receptor binding studies.

Application

• Neuroscientific Research: Used as a selective ligand to study the function of neurokinin-1 (NK1) receptors and the role of Substance P in pain transmission, inflammation, and neurogenic processes.
• Pharmacological Assay Development: Serves as a reference standard and competitive agent in receptor binding assays and functional cell-based tests to screen for novel NK1 receptor antagonists.
• Biochemical Pathway Analysis: Employed to elucidate intracellular signaling cascades (e.g., involving phospholipase C and calcium mobilization) activated by Substance P fragment binding.
• Drug Discovery & Medicinal Chemistry: Provides a core structural template for the design and optimization of peptide mimetics and small-molecule therapeutics targeting neurokinin receptors.
• Academic & Institutional Research: A fundamental reagent for university and government laboratories conducting basic research on neuropeptides and their physiological roles.

Basic Information

Product Name	Substance P (5-11)
CAS No.	51165-09-4
Molecular Formula	C38H62N12O9S
Molecular Weight	862.0 g/mol
Synonyms	Substance P Fragment 5-11; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (5-11); SP (5-11); [pGlu5, MePhe8, Sar9]-Substance P (5-11); Neurokinin P fragment; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH; Tachykinin fragment
EINECS	Contact for details

Quality Control

Our Substance P (5-11) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.