Description

Substance P (7-11) CAS NO 51165-05-0 is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 7 through 11. This fragment is a critical research tool for studying the structure-activity relationships of Substance P and its interaction with neurokinin receptors, particularly the NK1 receptor. It is essential for neuroscientists, pharmacologists, and biochemists engaged in neurological research, drug discovery for pain and inflammation, and the development of receptor-specific agonists or antagonists.

Application

• Neuroscience Research: Used as a selective ligand to study the binding and signaling mechanisms of the NK1 receptor in central and peripheral nervous systems.
• Pharmacological Studies: Serves as a reference standard and active agent in assays for screening and developing novel analgesic or anti-inflammatory compounds.
• Biochemical Analysis: Employed in structure-activity relationship (SAR) studies to understand the core pharmacophore of Substance P required for receptor activation.
• Cell Signaling Pathways: Utilized to investigate neurogenic inflammation, pain transmission, and the role of tachykinins in various physiological and pathological processes.
• Academic & Industrial R&D: A key reagent in university and pharmaceutical company laboratories for basic research and pre-clinical development stages.

Basic Information

Item	Details
Product Name	Substance P (7-11)
CAS No.	51165-05-0
Molecular Formula	C33H48N10O6S
Molecular Weight	712.86 g/mol
Synonyms	Substance P Fragment 7-11; Arg-Pro-Lys-Pro-Gln; SP (7-11); H-Arg-Pro-Lys-Pro-Gln-OH; Neurokinin P (7-11); Tachykinin Fragment 7-11
EINECS	Contact for details

Quality Control

Our Substance P (7-11) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0%
Water Content (KF)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.