Description

Pyroglutamyl-Seryl-Glycinamide is a synthetic tripeptide derivative, specifically a pyroglutamyl-modified peptide. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a key intermediate or structural motif in the synthesis of more complex peptides and neuroactive compounds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide synthesis, neuroscience studies, and the development of diagnostic agents.

Application

• Pharmaceutical Research & Development: As a crucial building block or reference standard in the synthesis of neuropeptides and other biologically active peptide sequences.
• Neuroscience Studies: Investigation of peptide interactions with receptors in the central nervous system, potentially related to neuromodulation.
• Biochemical Reagent: Used in enzymatic studies and as a substrate or inhibitor in assays to study specific peptidase or protease activity.
• Peptide Library Synthesis: Serves as a core structure for creating combinatorial peptide libraries for drug discovery and screening.
• Diagnostic Agent Development: Potential use in the development of labeled compounds for imaging or diagnostic tests targeting specific biological pathways.
• Fine Chemical Intermediate: A high-purity intermediate for the custom synthesis of more complex, target-specific peptide-based compounds for clients.

Basic Information

Product Name	Pyroglutamyl-Seryl-Glycinamide
CAS No.	51095-58-0
Molecular Formula	C13H21N5O6
Molecular Weight	343.34 g/mol
Synonyms	pGlu-Ser-Gly-NH2; Pyroglutamylserylglycinamide; 5-Oxo-L-prolyl-L-serylglycinamide; L-Pyroglutamyl-L-seryl-glycinamide; TRH Fragment (1-3); Thyrotropin-Releasing Hormone (1-3); pGlu-Ser-Gly amide; (S)-2-((S)-2-(5-Oxopyrrolidine-2-carboxamido)-3-hydroxypropanamido)acetamide
EINECS	Contact for details

Quality Control

Our Pyroglutamyl-Seryl-Glycinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide Certificates of Analysis (COA) with detailed specifications for traceability and assurance. Our quality commitment aligns with the standards expected for research-grade and GMP-starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.