Description

(-)-o-Acetyl-D-Mandelic Acid is a high-purity chiral building block and resolving agent of significant importance in asymmetric synthesis. Its specific stereochemistry makes it a valuable intermediate for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and advanced material sectors, where precise molecular configuration is critical for activity and performance.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system drugs.
• Asymmetric Synthesis & Resolution: Used as a resolving agent to separate enantiomers of racemic mixtures, enabling the production of single-isomer compounds.
• Agrochemical Development: Serves as a building block for creating enantiopure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Synthesis: Employed in the preparation of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable tool in methodological development for new catalytic asymmetric reactions and process chemistry.
• Ligand & Catalyst Preparation: Used to synthesize chiral ligands for metal-catalyzed reactions, enhancing selectivity and yield.

Basic Information

Product Name	(-)-o-Acetyl-D-Mandelic Acid
CAS No.	51019-43-3
Molecular Formula	C10H10O5
Molecular Weight	210.18 g/mol
Synonyms	(-)-O-Acetyl-D-mandelic acid; (R)-(-)-2-Acetoxy-2-phenylacetic acid; D-(-)-O-Acetylmandelic acid; (R)-O-Acetylmandelic acid; (2R)-2-Acetoxy-2-phenylacetic acid; (-)-α-Acetoxyphenylacetic acid; (R)-α-Acetoxyphenylacetic acid; LFA-344
EINECS	Contact for details

Quality Control

Our (-)-o-Acetyl-D-Mandelic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to exclude moisture and light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	118°C - 122°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.