Description

Somatostatin, Ala(3,14)- is a synthetic analogue of the endogenous peptide hormone somatostatin, modified with alanine substitutions at positions 3 and 14. This modification is designed to enhance its metabolic stability and receptor selectivity, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers focusing on endocrinology, neurobiology, and oncology. The compound, identified by CAS No. 50997-12-1, is essential for studies involving growth hormone regulation, receptor binding assays, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of somatostatin receptor (SSTR) subtypes, their signaling pathways, and physiological functions.
• Pharmacological Development: Serves as a key intermediate or lead compound in the design and screening of new peptide-based therapeutics targeting hormonal disorders and cancers.
• Endocrinology Studies: Applied in in vitro and in vivo models to investigate the inhibition of growth hormone (GH), insulin, and glucagon secretion.
• Neuroscience Research: Utilized to explore the role of somatostatin as a neurotransmitter/neuromodulator in the central and peripheral nervous systems.
• Diagnostic Tool Development: Acts as a ligand in the development of radio-labeled tracers for imaging techniques like PET and SPECT to visualize SSTR-expressing tumors.
• Cell Culture & Signal Transduction: Employed in cell-based assays to study receptor internalization, G-protein coupling, and downstream cellular effects.

Basic Information

Item	Details
Product Name	Somatostatin, Ala(3,14)-
CAS No.	50997-12-1
Molecular Formula	C76H104N18O19S2
Molecular Weight	1637.9 g/mol
Synonyms	Ala(3,14)-Somatostatin; [Ala³,Ala¹⁴]-Somatostatin-14; Somatostatin (3,14-dialanine); H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (cyclic 3-14 disulfide); SRIF analogue; SSTR ligand; Growth hormone release-inhibiting factor analogue
EINECS	Contact for details

Quality Control

Our Somatostatin, Ala(3,14)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results to ensure compliance with your research specifications. For specific purity grades or custom quality protocols, please contact our technical support team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.