Description

Droxidopa CAS NO 50731-20-9 is a synthetic amino acid analog that functions as a prodrug to norepinephrine. This compound is of significant commercial and therapeutic importance as a key active pharmaceutical ingredient (API) used in the treatment of neurogenic orthostatic hypotension. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of neurological and cardiovascular medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for neurogenic orthostatic hypotension (NOH).
• Neurological Research: Used in preclinical and clinical studies investigating autonomic nervous system disorders and Parkinson's disease.
• Cardiovascular Drug Development: Employed in R&D for drugs targeting blood pressure regulation and related dysautonomias.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Intermediate Synthesis: Can be utilized as a chiral building block in the synthesis of more complex neuroactive compounds.

Basic Information

Product Name	Droxidopa
CAS No.	50731-20-9
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	L-DOPS; L-Threo-DOPS; (-)-Three-DOPS; SM-5688; Droxidopa; L-Threo-3,4-Dihydroxyphenylserine; (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; Northera (brand name)
EINECS	Contact for details

Quality Control

Our Droxidopa is manufactured under strict quality management systems. It undergoes rigorous analytical testing to meet high-purity standards suitable for pharmaceutical applications, including identity, purity, and impurity profile verification. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from tests such as HPLC assay, chiral purity, residual solvents, and heavy metals to ensure compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (L-Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.