Description

Vecuronium Bromide is a non-depolarizing neuromuscular blocking agent belonging to the aminosteroid class, widely recognized for its critical role in modern anesthesia. Its primary value lies in providing controlled skeletal muscle relaxation during surgical procedures, facilitating optimal conditions for intubation and operation. This high-purity pharmaceutical intermediate is essential for manufacturers in the pharmaceutical and biopharmaceutical sectors producing injectable anesthetic formulations.

Application

• Active Pharmaceutical Ingredient (API): Core component in the manufacture of sterile injectable solutions for surgical muscle relaxation.
• Anesthesia Adjunct: Used to induce paralysis during general anesthesia, aiding in tracheal intubation and mechanical ventilation.
• Surgical Muscle Relaxation: Facilitates abdominal and thoracic surgeries by providing profound neuromuscular blockade.
• Critical Care Medicine: Employed in intensive care units (ICUs) to manage patients requiring prolonged mechanical ventilation.
• Pharmacological Research: Serves as a reference standard and key material in studies related to neuromuscular junction physiology and anesthetic development.
• GMP Manufacturing: Supplied as a building block for contract development and manufacturing organizations (CDMOs) operating under Good Manufacturing Practices.

Basic Information

Product Name	Vecuronium Bromide
CAS No.	50700-72-6
Molecular Formula	C34H57BrN2O4
Molecular Weight	637.74 g/mol
Synonyms	Norcuron; Org NC 45; 1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide; Vecuronium; Pipecuronium Bromide related compound A (USP); (2β,3α,5α,16β,17β)-2,16-Bis(1-methylpiperidinium-1-yl)-3,17-diacetoxy-androstane dibromide
EINECS	256-674-1

Quality Control

Our Vecuronium Bromide is manufactured and tested to meet exacting standards for pharmaceutical use. Quality is assured through a comprehensive battery of analytical tests, including HPLC for purity and related substances, identification by IR and NMR, and stringent limits for residual solvents and heavy metals. We support regulatory compliance with full traceability and provide Certificates of Analysis (COA) that detail conformance to relevant pharmacopeial monographs (e.g., USP, EP) or customer-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	[α]20/D: +30° to +36° (c=1 in CHCl3)
Bacterial Endotoxins	< 10.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.