Description

L-Proline, 1-[(2,4-Dichlorophenoxy)Acetyl]-4-Hydroxy-, trans- is a specialized synthetic derivative of the amino acid L-proline, featuring a substituted phenoxyacetyl group. This compound is valued for its role as a key chiral intermediate and building block in advanced organic synthesis, particularly for pharmaceuticals and agrochemicals. It is essential for research and development chemists in the life sciences sector who require high-purity, structurally complex intermediates to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential drug candidates, especially those targeting enzyme inhibition.
• Agrochemical Research: Used in the development of novel herbicides and plant growth regulators, leveraging the bioactive 2,4-dichlorophenoxy moiety.
• Peptidomimetics & Protease Inhibitors: The proline core structure makes it valuable for creating peptidomimetic compounds and inhibitors for proteolytic enzymes.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study biological pathways and protein functions.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: The chiral centers provide a scaffold for developing ligands used in asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific chiral intermediates.

Basic Information

Product Name	L-Proline, 1-[(2,4-Dichlorophenoxy)Acetyl]-4-Hydroxy-, trans-
CAS No.	50649-02-0
Molecular Formula	C₁₃H₁₃Cl₂NO₅
Molecular Weight	334.15 g/mol
Synonyms	trans-4-Hydroxy-L-proline, 1-[(2,4-dichlorophenoxy)acetyl]-; (2S,4R)-1-[(2,4-Dichlorophenoxy)acetyl]-4-hydroxypyrrolidine-2-carboxylic acid; 1-(2,4-Dichlorophenoxyacetyl)-4-hydroxy-L-proline; 4-Hydroxy-1-(2,4-dichlorophenoxyacetyl)-L-proline; L-Proline, 1-[(2,4-dichlorophenoxy)acetyl]-4-hydroxy-, (trans)-; 1-(2,4-Dichlorophenoxyacetyl)-trans-4-hydroxy-L-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 1-[(2,4-Dichlorophenoxy)Acetyl]-4-Hydroxy-, trans- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical and advanced research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.