Description

Insulin, (2-Nitro-4-Azidophenyl)(A1)- is a chemically modified insulin derivative, specifically functionalized with a photoreactive aryl azide group. This compound is of significant value in biochemical and pharmaceutical research as a versatile photoaffinity labeling agent, enabling the study of insulin receptor interactions and binding sites. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in proteomics, hormone action studies, and drug discovery.

Application

• Photoaffinity Labeling Studies: Used to covalently cross-link and identify insulin receptor subunits and binding proteins upon UV light activation.
• Biochemical Research: A critical tool for mapping the insulin-binding domains on its receptor and understanding signal transduction mechanisms.
• Proteomics and Target Identification: Employed to isolate and characterize proteins that interact with insulin in complex biological mixtures.
• Drug Discovery Platforms: Serves as a probe in high-throughput screening assays to discover and evaluate novel insulin mimetics or receptor modulators.
• Structural Biology: Aids in the structural analysis of insulin-protein complexes through the introduction of a specific cross-linking point.
• Diagnostic Development: Can be utilized in the development of advanced diagnostic assays for insulin-related metabolic disorders.

Basic Information

Product Name	Insulin, (2-Nitro-4-Azidophenyl)(A1)-
CAS No.	50645-87-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NαA1-(2-Nitro-4-azidophenyl)insulin; 2-Nitro-4-azidophenyl-A1-insulin; Photoaffinity Insulin Derivative; Insulin aryl azide derivative; Insulin photoreactive probe; A1-Modified Insulin; Insulin (2-nitro-4-azidophenyl) derivative
EINECS	Contact for details

Quality Control

Our Insulin, (2-Nitro-4-Azidophenyl)(A1)- is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, biological activity (where applicable), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under desiccant and allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere if possible.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC/ MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.