Description

Angiotensin II, Sar(1)-Gly(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at positions 1 and 8. This compound is a critical research tool and reference standard for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions focused on cardiovascular pharmacology, hypertension research, and the development of novel therapeutic agents targeting angiotensin receptors.

Application

• Pharmacological Research: Acts as a potent, selective agonist for studying Angiotensin II type 1 (AT1) receptor signaling pathways and physiological responses.
• Reference Standard: Serves as a high-purity analytical standard for the quantification and validation of Angiotensin II and its analogs in biological samples and pharmaceutical formulations.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays and in vitro/in vivo studies to evaluate the efficacy of potential AT1 receptor antagonists and other cardiovascular drugs.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the molecular interactions between peptide ligands and their receptors.
• Educational & Diagnostic Use: Applied in academic settings for teaching advanced endocrinology and in the development of diagnostic assays related to the renin-angiotensin system.

Basic Information

Product Name	Angiotensin II, Sar(1)-Gly(8)-
CAS No.	50642-32-5
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Sar¹, Gly⁸]-Angiotensin II; Saralasin Acetate; 1-Sarcosine-8-glycine-angiotensin II; Sar¹-Gly⁸-Angiotensin II; (Sar¹, Gly⁸)-Ang II; NSC-113939; Angiotensin II antagonist; Sarlasin
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Gly(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results to ensure the material meets the stringent requirements for pharmaceutical and biomedical research. Specifications can be aligned with relevant pharmacopeial guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the product should be stored in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Solubility	Soluble in water, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.