Description

n-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-4-o-(2,6-Diamino-2,6-Dideoxy-α-D-Glucopyranosyl)-D-Streptamine is a semi-synthetic aminoglycoside antibiotic derivative, representing a key intermediate in the synthesis of advanced therapeutic agents. Its complex structure is engineered to enhance efficacy and combat resistance, making it a critical component for pharmaceutical research and development. This high-purity compound is essential for manufacturers and research institutions focused on developing next-generation antibiotics and conducting microbiological studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel aminoglycoside antibiotics, such as amikacin and its analogs.
• Antibacterial Research: Used in microbiological and biochemical research to study mechanisms of action, resistance, and structure-activity relationships (SAR) of aminoglycosides.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step GMP-compliant production of finished antibiotic drug substances.
• Bioconjugation Studies: Utilized in research exploring the conjugation of antibiotics to other molecules to enhance targeting or delivery.

Basic Information

Product Name	n-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-4-o-(2,6-Diamino-2,6-Dideoxy-α-D-Glucopyranosyl)-D-Streptamine
CAS No.	50474-68-5
Molecular Formula	C22H43N5O13
Molecular Weight	585.61 g/mol
Synonyms	1-N-[(S)-4-Amino-2-hydroxybutyryl]-2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine; 1-N-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A; Amikacin Intermediate; 1-N-AHB-Kanamycin A; Kanamycin A 1-N-[(S)-4-Amino-2-hydroxybutyryl] derivative; Antibiotic BB-K 8 intermediate; (S)-O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-N1-(4-amino-2-hydroxybutyryl)-D-streptamine
EINECS	Contact for details

Quality Control

Our n-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-4-o-(2,6-Diamino-2,6-Dideoxy-α-D-Glucopyranosyl)-D-Streptamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical research and development. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.