Description

Histamine, n-Trifluoro-2-Fluoro- is a fluorinated derivative of the biogenic amine histamine, characterized by its unique trifluoro and fluoro substitutions. This structural modification is crucial for enhancing metabolic stability and altering receptor binding affinity, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily sought by medicinal chemists and research institutions engaged in the synthesis of novel histamine receptor ligands, diagnostic probes, and potential therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel histamine H3 and H4 receptor antagonists and agonists.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on drug potency and pharmacokinetics.
• Biochemical Tracer Development: Serves as a precursor for radiolabeled (e.g., with Fluorine-18) compounds used in Positron Emission Tomography (PET) imaging.
• Chemical Biology Probes: Utilized to create activity-based probes for studying histamine-related enzymatic pathways and receptor functions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Histamine, n-Trifluoro-2-Fluoro-
CAS No.	50444-84-3
Molecular Formula	C5H8F4N3
Molecular Weight	186.13 g/mol
Synonyms	2-Fluoro-α,α,α-trifluorohistamine; 1H-Imidazole-4-ethanamine, 2-fluoro-α,α,α-trifluoro-; α,α,α-Trifluoro-2-fluorohistamine; 2-Fluoro-α-trifluoromethylhistamine; 4-(2-Aminoethyl)-2-fluoro-5-(trifluoromethyl)imidazole; F-Fluorohistamine (trifluoromethyl); Histamine derivative, fluorinated; F4-Histamine
EINECS	Contact for details

Quality Control

Our Histamine, n-Trifluoro-2-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.