Description

2-Fluoro-L-Histidine is a fluorinated derivative of the essential amino acid L-Histidine, where a fluorine atom is strategically substituted on the imidazole ring. This targeted modification is crucial for probing enzyme mechanisms and receptor interactions, particularly in biochemical and pharmacological research. It serves as a valuable building block for medicinal chemists and researchers in the pharmaceutical and biotechnology industries who are developing novel therapeutics and diagnostic tools.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of fluorinated drug candidates and molecular probes targeting histidine-utilizing enzymes.
• Biochemical Studies: Used to investigate enzyme kinetics, inhibition mechanisms, and protein structure-function relationships where histidine residues play a catalytic role.
• Proteomics & Metabolomics: Employed as a stable isotope-labeled or modified amino acid standard in mass spectrometry-based analytical workflows.
• Peptide Synthesis: Serves as a specialized, fluorinated amino acid residue for creating modified peptides with altered stability, binding affinity, or spectroscopic properties.
• Radiopharmaceutical Precursor: Potential precursor for the synthesis of fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging.
• Academic Research: Fundamental tool in university and institutional labs for studying bioorganic chemistry and fluorine's effects in biological systems.

Basic Information

Product Name	2-Fluoro-L-Histidine
CAS No.	50444-78-5
Molecular Formula	C6H8FN3O2
Molecular Weight	173.15 g/mol
Synonyms	(S)-2-Amino-3-(2-fluoro-1H-imidazol-4-yl)propanoic acid; L-2-Fluorohistidine; F-His; 2-F-His; 2-Fluoro-histidine; 2-Fluorohistidine; (S)-2-Fluorohistidine; 2-Fluoro-1H-imidazole-4-propanoic acid, α-amino-, (S)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-L-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.