Description

H-His-Pro-Phe-His-Leu-D-Leu-Val-Tyr-Oh is a synthetic nonapeptide featuring a D-amino acid substitution, which confers enhanced metabolic stability and unique conformational properties. This structural modification makes it a valuable tool for advanced biochemical research and pharmaceutical development, particularly in the study of peptide-receptor interactions and enzyme inhibition. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, proteomics, and metabolic pathway analysis.

Application

• Biochemical Research: Used as a reference standard or substrate in enzymatic assays and receptor binding studies.
• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic peptides.
• Proteomics & Metabolomics: Employed in mass spectrometry and chromatography as a calibration standard or for method development.
• Academic Studies: Utilized in university laboratories for investigating peptide structure-activity relationships (SAR) and stability.
• Enzyme Inhibition Studies: Acts as a potential inhibitor or modulator for specific proteases or kinases due to its unique sequence.
• Peptide Library Synthesis: A component in the construction of combinatorial peptide libraries for high-throughput screening.

Basic Information

Product Name	H-His-Pro-Phe-His-Leu-D-Leu-Val-Tyr-Oh
CAS No.	50410-01-0
Molecular Formula	C55H75N13O10
Molecular Weight	1062.3 g/mol
Synonyms	Histidyl-Prolyl-Phenylalanyl-Histidyl-Leucyl-D-Leucyl-Valyl-Tyrosine; Nonapeptide H-HP-F-H-L-(D-L)-V-Y-OH; H-His-Pro-Phe-His-Leu-D-Leu-Val-Tyr; 50410-01-0; H-HP-F-H-L-(D-L)-V-Y-OH; HP-F-H-L-(D-L)-V-Y; His-Pro-Phe-His-Leu-D-Leu-Val-Tyr
EINECS	Contact for details

Quality Control

Our H-His-Pro-Phe-His-Leu-D-Leu-Val-Tyr-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to verify the D-amino acid content. Certificates of Analysis (COA) detailing purity, residual solvents, and other critical parameters are provided to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Chiral Purity (D-Leu)	≥ 98.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.