Description

2',3'-Di-o-Benzoyluridine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides and modified RNA molecules. Its primary value lies in providing selective protection for the ribose hydroxyl groups, preventing unwanted side reactions during complex chemical synthesis. This high-purity intermediate is critically needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of nucleotide-based therapeutics, including antisense oligonucleotides and siRNA.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase assembly of RNA and DNA strands.
• Prodrug Development: Serves as a precursor for designing lipophilic prodrugs of nucleoside analogs to enhance cellular uptake.
• Biochemical Research: Employed in academic and industrial labs for studying RNA structure, function, and metabolism.
• Labeled Compound Synthesis: Acts as a starting material for introducing isotopic labels (e.g., 13C, 15N) into nucleic acids for tracer studies.
• Catalyst and Ligand Preparation: Can be utilized to create specialized ligands for metal catalysis or as a chiral pool synthon.

Basic Information

Product Name	2',3'-Di-o-Benzoyluridine
CAS No.	50408-20-3
Molecular Formula	C23H20N2O8
Molecular Weight	452.42 g/mol
Synonyms	2',3'-Di-O-benzoyluridine; Uridine, 2',3'-di-O-benzoate; 2',3'-Dibenzoyluridine; 1-[(2R,3R,4R,5R)-3,4-Bis(benzoyloxy)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2,3-Di-O-benzoyluridine; 2,3-Di-O-benzoyl-β-D-ribofuranosyluracil; 2',3'-O-Dibenzoyluridine
EINECS	Contact for details

Quality Control

Our 2',3'-Di-o-Benzoyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.