Description

L-Tryptophan, [Side Chain-3-14C]- is a carbon-14 labeled isotopologue of the essential amino acid L-Tryptophan, specifically radiolabeled at the 3-position of the indole side chain. This compound is a critical tool for advanced metabolic and pharmacokinetic research, enabling precise tracking of tryptophan and its derivative pathways in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in the fields of biochemistry, neurochemistry, and drug discovery.

Application

• Tracer Studies in Metabolism: Used to investigate the biosynthesis and catabolism of proteins, serotonin, melatonin, and niacin (Vitamin B3).
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracing the absorption, distribution, metabolism, and excretion (ADME) of novel pharmaceutical compounds that interact with tryptophan pathways.
• Neurochemical Research: Enables detailed studies on serotonin synthesis and regulation in the central nervous system, relevant to mood and sleep disorder research.
• Protein Turnover and Synthesis Analysis: Applied in cell culture and animal models to measure rates of protein synthesis and degradation in specific tissues.
• Agricultural and Nutritional Biochemistry: Used in studies examining amino acid utilization, feed efficiency, and metabolic pathways in livestock and plants.
• Quality Control Reference Standard: Serves as an internal standard in analytical methods such as LC-MS for the quantification of tryptophan and related metabolites.

Basic Information

Product Name	L-Tryptophan, [Side Chain-3-14C]-
CAS No.	50373-34-7
Molecular Formula	C11H1214CN2O2
Molecular Weight	~207.2 g/mol (for 12C/1H form; exact mass varies with 14C enrichment)
Synonyms	(S)-2-Amino-3-(3-14C-indolyl)propionic Acid; L-α-Amino-1H-indole-3-propanoic acid (side chain-3-14C); [3-14C]-L-Tryptophan; Tryptophan-3-14C; L-TRP-3-14C; Radiolabeled Tryptophan; Carbon-14 Labeled Tryptophan
EINECS	Contact for details

Quality Control

Every batch of L-Tryptophan, [Side Chain-3-14C]- is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure compliance with specifications for radiochemical purity, chemical purity, and specific activity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, radio-HPLC, NMR, and mass spectrometry analyses. Our quality commitment supports research requiring the highest standards of traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage of solutions, aliquot and store under inert atmosphere at recommended temperatures. Follow all applicable local and international regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solubility	Soluble in dilute acid, alkali; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.