Description

8-Chloro-6-(2-Chlorophenyl)-N,n-Dimethyl-4H-1,2,4-Triazolo(1,5-A)(1,4)Benzodiazepine-2-Carboxamide is a high-purity, advanced pharmaceutical intermediate belonging to the triazolobenzodiazepine class. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel triazolobenzodiazepine derivatives with potential pharmacological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new compounds for CNS disorders.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Preclinical Development: Employed in the early-stage development of new chemical entities (NCEs) for various therapeutic areas.
• Academic Research: Utilized in university and institutional labs for studying benzodiazepine receptor interactions and drug design.
• Process Chemistry: Acts as a starting material or intermediate in optimizing scalable synthetic routes for potential drug candidates.

Basic Information

Product Name	8-Chloro-6-(2-Chlorophenyl)-N,n-Dimethyl-4H-1,2,4-Triazolo(1,5-A)(1,4)Benzodiazepine-2-Carboxamide
CAS No.	50330-59-1
Molecular Formula	C19H15Cl2N5O
Molecular Weight	400.26 g/mol
Synonyms	8-Chloro-6-(2-chlorophenyl)-N,N-dimethyl-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide; 50330-59-1; Triazolobenzodiazepine Carboxamide Derivative; Loprazolam Impurity; Loprazolam Related Compound; UNII-8V4L6V3P3I; 8V4L6V3P3I
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-(2-Chlorophenyl)-N,n-Dimethyl-4H-1,2,4-Triazolo(1,5-A)(1,4)Benzodiazepine-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.