Description

Z-Trp-Osu (CAS NO 50305-28-7) is a high-purity, activated ester derivative of tryptophan, specifically designed for peptide synthesis and bioconjugation. This compound is a critical reagent for the efficient and selective formation of amide bonds under mild conditions, enabling the precise construction of complex biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel peptide-based therapeutics, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated amino acid building block for the controlled incorporation of tryptophan residues into peptide chains.
• Solution-Phase Peptide Coupling: Facilitating amide bond formation in solution for the synthesis of short peptides or peptide fragments.
• Bioconjugation and Labeling: Conjugating peptides, proteins, or other biomolecules with fluorescent dyes, tags, or drug molecules via amine-reactive chemistry.
• Pharmaceutical Intermediate: Serving as a key synthetic intermediate in the research and development of peptide-active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in the study of protein-protein interactions, enzyme substrates, and receptor ligands.
• Material Science: Functionalizing surfaces or polymers with bioactive peptide sequences for biomedical applications.

Basic Information

Product Name	Z-Trp-Osu
CAS No.	50305-28-7
Molecular Formula	C21H19N3O6
Molecular Weight	409.39 g/mol
Synonyms	Nα-Carbobenzoxy-L-tryptophan N-hydroxysuccinimide ester; Z-L-Tryptophan N-succinimidyl ester; Cbz-L-Tryptophan OSuc ester; N-Cbz-L-Tryptophan succinimidyl ester; Nα-Cbz-L-Trp-OSu; Z-Tryptophan-OSu; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; Benzyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[(2,5-dioxopyrrolidin-1-yl)oxy]propan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Trp-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral purity verification, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.