Description

H-Thr-Leu-Oh is a high-purity dipeptide derivative composed of L-Threonine and L-Leucine. This compound serves as a critical building block and intermediate in advanced organic synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis sectors who require reliable, high-quality raw materials for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to construct longer peptide chains for research and therapeutic applications.
• Biochemical Research: Serves as a standard or substrate in enzymatic studies and metabolic pathway investigations.
• Proteomics & Molecular Biology: Utilized in the study of protein structure, function, and protein-protein interactions.
• Cosmetic Peptides: Potential intermediate for the development of bioactive peptides used in skincare and cosmetic formulations.
• Nutraceuticals: Investigated for use in the development of specialized nutritional supplements and functional foods.

Basic Information

Product Name	H-Thr-Leu-Oh
CAS No.	50299-12-2
Molecular Formula	C10H20N2O4
Molecular Weight	232.28 g/mol
Synonyms	L-Threonyl-L-leucine; H-Thr-Leu-OH; Thr-Leu; L-Thr-L-Leu; Threonylleucine; 2-[(2-Amino-3-hydroxybutanoyl)amino]-4-methylpentanoic acid; (2S,3S)-2-[(2S)-2-Amino-3-hydroxybutanamido]-4-methylpentanoic acid; N-[(2S,3S)-2-Amino-3-hydroxy-1-oxobutyl]-L-leucine
EINECS	Contact for details

Quality Control

Our H-Thr-Leu-Oh is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the exacting standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15° to -25° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.