Description

(R)-Phenprocoumon is the single enantiomer form of the anticoagulant drug phenprocoumon, specifically the (R)-enantiomer. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective drug metabolism and activity. It is primarily required by pharmaceutical companies, advanced research institutions, and fine chemical manufacturers engaged in developing or producing enantiomerically pure anticoagulant therapies and related biochemical studies.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure anticoagulant pharmaceuticals.
• Reference standard for analytical method development and validation in pharmacokinetic studies.
• Biochemical research tool for investigating the stereoselective metabolism and mechanism of action of vitamin K antagonists.
• Starting material for the preparation of deuterated or other isotopically labeled analogs for use as internal standards in LC-MS/MS bioanalysis.
• Active Pharmaceutical Ingredient (API) development for next-generation, targeted anticoagulant therapies.
• Substrate for enzymatic studies and assay development related to coagulation factors.

Basic Information

Product Name	(R)-Phenprocoumon
CAS No.	5999-27-9
Molecular Formula	C18H16O3
Molecular Weight	280.32 g/mol
Synonyms	(R)-3-(1-Phenylpropyl)-4-hydroxycoumarin; (R)-Marcoumar; (R)-Falithrom; (R)-Liquamar; Phenprocoumon, (R)-isomer; (R)-PPC; (R)-4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
EINECS	Contact for details

Quality Control

Our (R)-Phenprocoumon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and related substances are provided and can be tailored to meet client-specific pharmacopeial or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.