Description

4-Chloro-2-Methyl-6-Trifluoromethylpyrimidine is a versatile halogenated pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it a valuable precursor for creating compounds with tailored electronic and steric properties. This intermediate is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly for developing novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key synthon for the synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging the biological activity of the pyrimidine core.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing drug candidates, especially in areas targeting enzymes and receptors where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Material Science Research: Serves as a precursor for specialty chemicals, liquid crystals, and organic electronic materials due to its unique halogenated structure.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for creating complex molecular architectures.
• Nucleophilic Substitution: Acts as an electrophile in reactions with various nucleophiles (amines, alkoxides) to generate diversely substituted pyrimidine libraries for screening.
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine atoms or serves as a stable moiety in the design of compounds with improved physicochemical properties.

Basic Information

Product Name	4-Chloro-2-Methyl-6-Trifluoromethylpyrimidine
CAS No.	5993-98-6
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine; 2-Methyl-4-chloro-6-trifluoromethylpyrimidine; 6-Trifluoromethyl-4-chloro-2-methylpyrimidine; 4-Chloro-2-methyl-6-(trifluoromethyl)-1,3-diazine; Pyrimidine, 4-chloro-2-methyl-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methyl-6-Trifluoromethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your R&D and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.