Description

4-(4-Chloro-Phenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-purity pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those within the dihydropyrimidinone class. It is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydropyrimidinone (DHPM) based drugs, which exhibit a wide range of biological activities.
• API Synthesis: Used in the manufacturing of Active Pharmaceutical Ingredients (APIs) for potential therapeutic applications, including calcium channel modulators.
• Medicinal Chemistry Research: Employed as a scaffold in drug discovery programs for creating libraries of novel compounds with targeted biological properties.
• Fine Chemical Production: Serves as a specialized intermediate for producing high-value, complex organic molecules in custom synthesis projects.
• Academic & Industrial R&D: Utilized in research laboratories for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	4-(4-Chloro-Phenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	5948-71-0
Molecular Formula	C14H15ClN2O3
Molecular Weight	294.73 g/mol
Synonyms	Ethyl 4-(4-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate; 4-(4-Chlorophenyl)-6-methyl-3,4-dihydro-2(1H)-pyrimidinone-5-carboxylic Acid Ethyl Ester; Biginelli Reaction Product; DHPM Derivative; 5-Ethoxycarbonyl-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; 4-(p-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 4-(4-Chloro-Phenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.