Description

D,L-Alanosine is a synthetic, non-proteinogenic amino acid analog with significant biochemical research applications. Its primary value lies in its potent inhibitory action on adenylosuccinate synthetase, a key enzyme in the *de novo* purine biosynthesis pathway. This mechanism makes it a critical research tool for scientists in oncology, microbiology, and enzymology studying metabolic pathways, tumor cell proliferation, and antimicrobial strategies. Researchers and pharmaceutical developers seeking to investigate purine metabolism or explore novel therapeutic approaches will find this compound essential.

Application

• Oncology Research: Used as a metabolic inhibitor to study the effects of purine biosynthesis blockade on tumor cell growth and proliferation.
• Enzymology Studies: Serves as a specific inhibitor of adenylosuccinate synthetase (ADSS) for investigating purine nucleotide metabolism in vitro.
• Antimicrobial Research: Explored for its potential to inhibit the growth of microorganisms that rely on the *de novo* purine synthesis pathway.
• Biochemical Assay Development: Employed as a standard or reference compound in assays designed to measure ADSS activity or screen for modulators.
• Cell Culture & Metabolism: Utilized in cell-based studies to create purine-starved conditions, enabling research into nucleotide salvage pathways and cell cycle arrest.
• Pharmaceutical Intermediates: Acts as a key chiral building block or intermediate in the synthetic routes of more complex investigational compounds.

Basic Information

Product Name	D,L-Alanosine
CAS No.	5854-95-5
Molecular Formula	C3H7N3O4
Molecular Weight	149.11 g/mol
Synonyms	L-Alanosine; NSC 153353; (S)-2-Amino-3-(hydroxynitrosoamino)propanoic acid; 3-(N-Hydroxy-N-nitrosoamino)-L-alanine; Alanosin; Antibiotic U-42126; SDX-102
EINECS	Contact for details

Quality Control

Our D,L-Alanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.