Description

Cyclo(-Leu-Gly) CAS NO 5845-67-0 is a cyclic dipeptide, also known as a diketopiperazine (DKP), formed from the amino acids L-leucine and glycine. This compound is a valuable synthetic intermediate and a structural motif of significant interest in pharmaceutical research and peptide chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications ranging from drug discovery to the development of novel biomaterials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a model compound in studies of peptide conformation, stability, and cyclization mechanisms.
• Drug Discovery Scaffold: Acts as a privileged scaffold in medicinal chemistry for designing new molecules with potential biological activity.
• Cosmetic Peptide Precursor: Can be utilized in the development of specialty peptides for advanced skincare and cosmetic formulations.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Cyclo(-Leu-Gly)
CAS No.	5845-67-0
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	Cyclo(L-leucyl-glycyl); 3-Isobutyl-2,5-piperazinedione; 3-Isobutylpiperazine-2,5-dione; L-Leucyl-glycine anhydride; Cyclo(L-leucyl-glycine); Diketopiperazine (Leu-Gly); DKPs; 2,5-Diketopiperazine derivative; (3S)-3-(2-Methylpropyl)piperazine-2,5-dione
EINECS	227-420-1

Quality Control

Our Cyclo(-Leu-Gly) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.